Buy MOTS-C 2026 — Mitochondrial-Derived Peptide for AMPK/Folate Cycle Research (EU)
MOTS-C at a glance
| Designation | MOTS-C (mitochondrially encoded peptide) |
|---|---|
| Identity | Mitochondrially encoded peptide of 16 amino acids, derived from the 12S rRNA region (MT-RNR1) |
| Synonyms | Mitochondrial peptide, MOTSc, MT-RNR1 peptide |
| Research context | AMPK activation, folate cycle, insulin sensitivity models (in vitro/animal model) |
| CAS number | See CoA (the batch-specific COA is authoritative) |
| Form | Lyophilised powder (freeze-dried), sealed vial |
| Amount | 10 mg per vial |
| Purity | ≥99% (HPLC), identity confirmed by LC-MS |
| Analysis | External third-party laboratory, batch-specific COA |
| Intended use | For Research Use Only (RUO) |
| Price | €49.90 · Shipping from Germany |
What is MOTS-C?
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a mitochondrially encoded peptide, which originates not from the nuclear genome, but from the mitochondrial genome. It consists of 16 amino acids and is from the 12S rRNA gene region MT-RNR1 derived. MOTS-C therefore belongs to the group of so-called Mitochondrial-Derived Peptides (MDPs) – short peptides encoded by mitochondrial DNA, which are described in research as a distinct substance class. MOTS-C is supplied as a stable lyophilised product in a sealed vial (10 mg). In laboratory research, it serves as a defined reference substance. The CAS number and molecular formula are documented in the batch-specific analysis certificate.
Molecular profile & target structure
MOTS-C is a linear peptide of 16 amino acids. Its distinguishing feature is the mitochondrial origin: the coding sequence lies within the 12S rRNA region of the mitochondrial MT-RNR1 locus, which is why MOTS-C is used in the literature as a model for mitochondrially encoded peptides and their signalling function. Due to its manageable length, defined sequence and good analytical characterisability, its purity can be reliably determined by HPLC and its identity confirmed by mass spectrometry via molecular mass. These properties make MOTS-C a frequently used reference in cell biology and metabolism-related study models.
What in-vitro and animal model studies document
The following summary reflects only what is described in the publicly accessible preclinical literature – it is not a statement about an effect or suitability in humans.
- AMPK activation Published in vitro and animal model studies investigate MOTS-C in the context of activating AMP-activated protein kinase (AMPK), an energy metabolism switch widely described in cell biology.
- Folate cycle: Several studies document observations on the folate cycle and associated one-carbon metabolism in cell models.
- Insulin sensitivity models: Preclinical studies describe MOTS-C in the context of insulin sensitivity models and glucose metabolism in cell and animal models.
- Mitochondrial signal peptides: MOTS-C is used as a reference example for the investigation of mitochondrially encoded peptides and their signalling function in basic research.
These observations originate from in vitro and animal models. They underpin the research interest in MOTS-C, but do not provide any statements on safety, efficacy, or application beyond laboratory research.
Purity, COA & Analytical Testing
Purity and identity are the two values that count. HPLC demonstrates purity (target value ≥ 99 %), LC-MS confirms the identity via molecular mass. Both values are listed on the batch-related COA. We explain how to read such a certificate in Understanding and reading a Certificate of Analysis (COA); the procedures themselves in Peptide Purity: HPLC and LC-MS Explained.
Storage & Handling
As a lyophilised product, MOTS-C is stable when stored is kept cool, dry and protected from light and stored – ideally at -20°C for longer storage. Please refer to the COA for batch-specific information. Principles: Storing and Handling Research Peptides.
Buying MOTS-C in the EU – what matters
What matters is not the price, but this: Does the label match the contents? Here's what BlitzLab delivers on:
- Batch-specific COA from a third-party laboratory – HPLC (purity) and LC-MS (identity), carried out externally, not by us.
- EU Shipping, discreetly packaged, with tracking – usually 2–5 working days.
- Transparent RUO stance – clear labelling, complete Compliance page, no claims of efficacy or cure.
What else to look out for with a reputable provider: 7-point checklist.
Frequently asked questions about buying MOTS-C
Note on Sources & RUO
This guide summarises publicly available preclinical research literature (in-vitro and animal models) on MOTS-C. The accompanying Certificate of Analysis is always authoritative for the identity, CAS number, molecular formula and purity of the supplied batch. All information is for research use only and does not constitute medical advice, dosage or application recommendations.
Certificate of Analysis, specification, and availability directly on the product page.