Buy TB-500 2026 — Thymosin β4 Fragment for Actin & Cell Migration Research (EU)

Peptide Research · 28 June 2026 · 11 min read · Research Use Only

TB-500 at a glance

What is TB-500?

TB-500 is a synthetic fragment of the protein thymosin β4, a small polypeptide that occurs naturally in many tissues. While full-length thymosin β4 consists of several dozen amino acids, in research nomenclature TB-500 refers to the active fragment of this protein, which is synthetically produced and used in pre-clinical studies. It is supplied as a stable lyophilisate in a sealed vial (10 mg). In laboratory research, TB-500 serves as a defined reference substance for studies relating to the cytoskeletal protein actin. The CAS number and molecular formula are documented in the batch-specific certificate of analysis.

Molecular profile & target structure

Thymosin β4 belongs to the β-thymosin family, whose common feature is a binding region for monomeric Actin is – the protein that builds and remodels the cytoskeleton within cells. In the literature, the thymosin β4 fragment is therefore frequently used as a model system for the Actin binding and the dynamics of the cytoskeleton. The combination of a defined sequence, the characteristic actin-binding site and straightforward analytical characterisation makes this fragment a frequently used reference in cell biology model systems, particularly in studies of cell movement and angiogenesis.

What in-vitro and animal model studies document

The following summary reflects only what is described in the publicly accessible preclinical literature – it is not a statement about an effect or suitability in humans.

• Actin Binding Published in vitro studies investigate the thymosin β4 fragment in relation to its binding to monomeric actin and the dynamics of the cytoskeleton.
• Cell migration models: Several studies document observations on cell migration in cultured cell systems, in which the fragment serves as the subject of investigation.
• Angiogenesis Models The fragment is used in in vitro and animal models that replicate the processes of blood vessel formation (angiogenesis).
• Cytoskeletal research: A number of studies describe the fragment as a reference in research into the organisation and remodelling of the actin cytoskeleton.

These observations are based on in vitro and animal models. They underpin the research interest in TB-500, but do not provide any information regarding its safety, efficacy or use outside of laboratory research.

Purity, COA & Analytical Testing

Purity and identity are the two values that count. HPLC demonstrates purity (target value ≥ 99 %), LC-MS confirms the identity via molecular mass. Both values are listed on the batch-related COA. We explain how to read such a certificate in Understanding and reading a Certificate of Analysis (COA); the procedures themselves in Peptide Purity: HPLC and LC-MS Explained.

Storage & Handling

As a lyophilised powder, TB-500 is stable when stored is kept cool, dry and protected from light and stored – ideally at -20°C for longer storage. Please refer to the COA for batch-specific information. Principles: Storing and Handling Research Peptides.

Buying TB-500 in the EU – what matters

What matters is not the price, but this: Does the label match the contents? Here's what BlitzLab delivers on:

• Batch-specific COA from a third-party laboratory – HPLC (purity) and LC-MS (identity), carried out externally, not by us.
• EU Shipping, discreetly packaged, with tracking – usually 2–5 working days.
• Transparent RUO stance – clear labelling, complete Compliance page, no claims of efficacy or cure.

What else to look out for with a reputable provider: 7-point checklist.

Frequently asked questions about buying TB-500

Note on Sources & RUO

This guide summarises publicly available pre-clinical research literature (in vitro and animal models) on TB-500. The accompanying certificate of analysis is always the authoritative source for the identity, CAS number, molecular formula and purity of the batch supplied. All information is provided solely for research purposes (Research Use Only) and does not constitute medical advice, dosage recommendations or advice on use.